SCHEMBL7875670

SCHEMBL7875670

CC(C)C1CCC(=O)N(C)C1

nearest known ligand 0.44

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SRD5A1 P18405 7/20 0.44
SRD5A2 P31213 2/20 0.37
BRD4 O60885 8/20 0.37
BRD2 P25440 1/20 0.37
TACR1 P25103 1/20 0.33
CYP11B2 P19099 1/20 0.33
DDB1 Q16531 1/20 0.32
CRBN Q96SW2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23107036 1.00 SRD5A1 (0.44) SRD5A1SRD5A2BRD4BRD2TACR1
SCHEMBL24456727 1.00 SRD5A1 (0.44) SRD5A1SRD5A2BRD4BRD2TACR1
SCHEMBL23707186 0.82 SRD5A1 (0.41) SRD5A1SRD5A2BRD4BRD2TACR1
SCHEMBL21254092 0.82 BRD4 (0.45) SRD5A1SRD5A2BRD4BRD2
SCHEMBL18883352 0.78 BRD4 (0.47) SRD5A1BRD4DDB1CRBN
SCHEMBL18821181 0.78 BRD4 (0.47) SRD5A1BRD4DDB1CRBN
SCHEMBL7905602 0.78 BRD4 (0.47) SRD5A1BRD4DDB1CRBN
SCHEMBL13024157 0.78 ACE (0.32)
SCHEMBL9255662 0.78 MAPT (0.43)
SCHEMBL29333362 0.75 SRD5A1 (0.42) SRD5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025898-A1 HPK1 ANTAGONISTS AND USES THEREOF SCHRÖDINGER, INC. 2024-01-25 US disclosed
US-20240025898-A1 HPK1 ANTAGONISTS AND USES THEREOF SCHRÖDINGER, INC. 2024-01-25 US disclosed
WO-2023235880-A1 CD38 MODULATORS AND USES THEREOF AEOVIAN PHARMACEUTICALS, INC. (US) 2023-12-07 WO disclosed
US-11787780-B2 Quaternary indazole glucocorticoid receptor antagonists CORCEPT THERAPEUTICS INCORPORATED (US) 2023-10-17 US disclosed
US-11787780-B2 Quaternary indazole glucocorticoid receptor antagonists CORCEPT THERAPEUTICS INCORPORATED (US) 2023-10-17 US disclosed
EP-3724188-B1 PROGRANULIN MODULATORS AND METHODS OF USING THE SAME ARKUDA THERAPEUTICS (US) 2023-06-07 EP disclosed
US-20230117631-A1 HPK1 ANTAGONISTS AND USES THEREOF Nimbus Saturn, Inc. 2023-04-20 US disclosed
WO-2023014908-A1 LPAR1 ANTAGONISTS AND USES THEREOF Pipeline Therapeutics, Inc. (US) 2023-02-09 WO disclosed
US-20230032612-A1 QUATERNARY INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS CORCEPT THERAPEUTICS INCORPORATED 2023-02-02 US disclosed
US-20230012362-A1 WDR5 INHIBITORS AND MODULATORS VANDERBILT UNIVERSITY 2023-01-12 US disclosed
US-20160229831-A1 SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS ACUCELA INC. 2016-08-11 US disclosed
US-20160151369-A1 SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS ACUCELA INC. 2016-06-02 US disclosed
US-9133154-B2 Substituted 3-phenylpropylamine derivatives for the treatment of ophthalmic diseases and disorders ACUCELA INC. (US) 2015-09-15 US disclosed
US-20140275043-A1 SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS ACUCELA INC. (US) 2014-09-18 US disclosed
WO-2010123451-A1 SULPHIDE BRIDGED DERIVATIVES AS MODULATORS OF MGLUR5 ASTRAZENECA AB (SE) 2010-10-28 WO disclosed
US-4880901-A DICHLOROAROMATICS WITH SODIUM SULFIDE AND ONE TRIHALOAROMATIC, INJECTION MOLDING PHILLIPS PETROLEUM COMPANY (US) 1989-11-14 US disclosed
EP-0100551-B1 ARYLENE SULFIDE TERPOLYMERS AND PROCESSES FOR MAKING THEM PHILLIPS PETROLEUM COMPANY (US) 1987-07-15 EP disclosed
EP-0100551-A2 Arylene sulfide terpolymers and processes for making them PHILLIPS PETROLEUM COMPANY (US) 1984-02-15 EP disclosed
US-4405767-A ALKALI METAL SULFIDE, N-ALKYL LACTAM AND A POLYHALOAROMATIC COMPOUND PHILLIPS PETROLEUM COMPANY (US) 1983-09-20 US disclosed
US-4116947-A FROM P-DIHALOBENZENE, POLYHALO AROMATIC COMPOUND, ALKALI METAL SULFIDE, N-ALKYL LACTAM AND WATER PHILLIPS PETROLEUM COMPANY (US) 1978-09-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787780-B2 Quaternary indazole glucocorticoid receptor antagonists NR3C1, NR3C2, MC2R SRD5A1 70/4885SRD5A2 54/4885BRD4 1072/4885
US-20140275043-A1 SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS ALDH1A2, PSEN2, CLN6 SRD5A1 1481/4885SRD5A2 2012/4885BRD4 1317/4885
US-20230032612-A1 QUATERNARY INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS NR3C1, NR3C2, MC2R SRD5A1 70/4885SRD5A2 54/4885BRD4 1072/4885
US-20160229831-A1 SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS ALDH1A2, PSEN2, CLN6 SRD5A1 1481/4885SRD5A2 2012/4885BRD4 1317/4885
US-20230117631-A1 HPK1 ANTAGONISTS AND USES THEREOF PDXK, HIPK1, PCK1 SRD5A1 1787/4885SRD5A2 1879/4885BRD4 2720/4885
US-20230012362-A1 WDR5 INHIBITORS AND MODULATORS WDR5, WDR1, WDR77 SRD5A1 2573/4885SRD5A2 3257/4885BRD4 44/4885
US-20240025898-A1 HPK1 ANTAGONISTS AND USES THEREOF PDXK, HIPK1, PCK1 SRD5A1 1787/4885SRD5A2 1879/4885BRD4 2720/4885
US-20160151369-A1 SUBSTITUTED 3-PHENYLPROPYLAMINE DERIVATIVES FOR THE TREATMENT OF OPHTHALMIC DISEASES AND DISORDERS ALDH1A2, PSEN2, CLN6 SRD5A1 1481/4885SRD5A2 2012/4885BRD4 1317/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.