Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23102957 | 0.80 | LMNA (0.38) | LMNAGAATSHR | |
| SCHEMBL23109015 | 0.80 | LMNA (0.38) | LMNAGAATSHR | |
| SCHEMBL23103452 | 0.80 | LMNA (0.38) | LMNAGAATSHR | |
| SCHEMBL24859534 | 0.79 | LMNA (0.35) | LMNAGAATSHR | |
| SCHEMBL23109019 | 0.66 | GAA (0.39) | LMNAGAATSHR | |
| SCHEMBL24859533 | 0.66 | GAA (0.39) | LMNAGAATSHR | |
| SCHEMBL26820737 | 0.66 | MEN1 (0.34) | LMNA | |
| SCHEMBL23103551 | 0.66 | POLB (0.42) | LMNAGAATSHR | |
| SCHEMBL23103262 | 0.65 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL23103258 | 0.65 | SMN1; SMN2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078201-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists | Nimbus Saturn, Inc. (US) | 2021-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078201-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists | HIPK1, PDXK, IP6K1 | LMNA 2638/4885GAA 3731/4885TSHR 4490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.