Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 2/20 | 0.34 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31299280 | 0.82 | USP2 (0.61) | USP2SMN1; SMN2RECQLPIK3R1PIK3CA | |
| SCHEMBL16903431 | 0.82 | USP2 (0.61) | USP2SMN1; SMN2RECQLPIK3R1PIK3CA | |
| SCHEMBL31299440 | 0.82 | USP2 (0.61) | USP2SMN1; SMN2RECQLPIK3R1PIK3CA | |
| SCHEMBL13452494 | 0.82 | SMN1; SMN2 (0.61) | USP2SMN1; SMN2RECQLPIK3R1PIK3CA | |
| SCHEMBL31041013 | 0.81 | USP2 (0.59) | USP2SMN1; SMN2RECQLPIK3R1PIK3CA | |
| SCHEMBL24692803 | 0.81 | SMN1; SMN2 (0.59) | USP2SMN1; SMN2RECQLPIK3R1PIK3CA | |
| SCHEMBL25866966 | 0.81 | USP2 (0.63) | USP2SMN1; SMN2RECQLHPGDEPHX2 | |
| SCHEMBL30987056 | 0.80 | USP2 (0.58) | USP2SMN1; SMN2RECQLPIK3R1PIK3CA | |
| SCHEMBL27423987 | 0.80 | SMN1; SMN2 (0.58) | USP2SMN1; SMN2RECQLPIK3R1PIK3CA | |
| SCHEMBL15649307 | 0.79 | USP2 (0.61) | USP2SMN1; SMN2RECQLPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078201-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists | Nimbus Saturn, Inc. (US) | 2021-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078201-B2 | Substituted isoindolin-1-ones and 2,3-dihydro-1H-pyrrol[3,4-c]pyridin-1-ones as HPK1 antagonists | HIPK1, PDXK, IP6K1 | USP2 2229/4885SMN1; SMN2 2709/4885RECQL 1451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.