SCHEMBL23707491

SCHEMBL23707491

CC1CN(C(C)C(=O)Nc2ccc(Cl)cc2)CC1Oc1ccnc2ccc(F)cc12

nearest known ligand 0.59

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 20/20 0.59
CYP2C9 P11712 2/20 0.53
CYP3A4 P08684 2/20 0.53
CYP2C8 P10632 1/20 0.53
TDO2 P48775 1/20 0.53
KCNH2 Q12809 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23707490 0.88 IDO1 (0.65) IDO1CYP2C9CYP3A4CYP2C8TDO2
SCHEMBL24089848 0.88 IDO1 (0.65) IDO1CYP2C9CYP3A4CYP2C8TDO2
SCHEMBL17729160 0.85 IDO1 (0.66) IDO1CYP2C9CYP3A4CYP2C8TDO2
SCHEMBL23707432 0.83 IDO1 (0.65) IDO1CYP2C9CYP3A4CYP2C8TDO2
SCHEMBL30444768 0.83 IDO1 (0.62) IDO1CYP2C9CYP3A4CYP2C8TDO2
SCHEMBL23699118 0.83 IDO1 (0.62) IDO1CYP2C9CYP3A4CYP2C8TDO2
SCHEMBL23707462 0.81 IDO1 (0.49) IDO1CYP3A4
SCHEMBL18806746 0.79 IDO1 (0.68) IDO1
SCHEMBL23699077 0.79 IDO1 (0.53) IDO1CYP2C9CYP3A4CYP2C8TDO2
SCHEMBL30444764 0.79 IDO1 (0.53) IDO1CYP2C9CYP3A4CYP2C8TDO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3858813-A1 QUINOLONE DERIVATIVE HAVING INDOLEAMINE-2,3-DIOXYGENASE INHIBITED ACTIVITY Shenzhen Chipscreen Biosciences Co., Ltd. (CN) 2021-08-04 EP disclosed