Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MLYCD | O95822 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11402078 | 0.84 | EPHX1 (0.63) | KMT2AMEN1CYP2D6CYP2C19KDM4E | |
| SCHEMBL10619104 | 0.83 | RORC (0.62) | KMT2AMEN1ALDH1A1CYP3A4MAPT | |
| SCHEMBL7521127 | 0.81 | NPC1 (0.52) | KMT2AMEN1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL13390859 | 0.81 | KDM4E (0.64) | KMT2AMEN1CYP2D6CYP2C19KDM4E | |
| SCHEMBL24723675 | 0.80 | TSHR (0.66) | KMT2AMEN1KDM4EALDH1A1RECQL | |
| SCHEMBL10616241 | 0.80 | CYP3A4 (0.58) | KMT2AMEN1ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL23709491 | 0.80 | KDM4E (0.55) | KMT2AMEN1CYP2D6CYP2C19KDM4E | |
| SCHEMBL11569897 | 0.80 | KDM4E (0.62) | KMT2AMEN1CYP2D6CYP2C19KDM4E | |
| SCHEMBL11510981 | 0.80 | KMT2A (0.58) | KMT2AMEN1CYP2D6CYP2C19KDM4E | |
| SCHEMBL23709701 | 0.80 | KMT2A (0.48) | KMT2AMEN1CYP2D6CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | NAVITOR PHARMACEUTICALS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. | 2021-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210238165-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | RHEB, KRAS, NRAS | KMT2A 2481/4885MEN1 254/4885CYP2D6 2143/4885 |
| US-11339144-B2 | Heteroaryl Rheb inhibitors and uses thereof | RHEB, GDI2, KRAS | KMT2A 3149/4885MEN1 169/4885CYP2D6 2752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.