Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2371857 | 0.86 | BACE1 (0.42) | BACE1CTSD | |
| SCHEMBL2370178 | 0.84 | BACE1 (0.62) | BACE1KCNH2CTSD | |
| SCHEMBL2370685 | 0.82 | BACE1 (0.37) | BACE1KCNH2 | |
| SCHEMBL2371012 | 0.81 | BACE1 (0.39) | BACE1CTSD | |
| SCHEMBL2369861 | 0.80 | — | — | |
| SCHEMBL2371375 | 0.75 | BACE1 (0.62) | BACE1KCNH2CTSD | |
| SCHEMBL2371566 | 0.75 | CTSD (0.32) | BACE1CTSD | |
| SCHEMBL2370968 | 0.73 | BACE1 (0.72) | BACE1KCNH2CTSD | |
| SCHEMBL2370974 | 0.73 | BACE1 (0.72) | BACE1KCNH2CTSD | |
| SCHEMBL2371007 | 0.73 | BACE1 (0.46) | BACE1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547686-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115928-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |