Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2371282 | 0.84 | BACE1 (0.52) | CTSDBACE1BACE2 | |
| SCHEMBL2369861 | 0.80 | — | — | |
| SCHEMBL2371857 | 0.75 | BACE1 (0.42) | CTSDBACE1BACE2 | |
| SCHEMBL2370970 | 0.75 | BACE1 (0.42) | CTSDBACE1 | |
| SCHEMBL2371012 | 0.74 | BACE1 (0.39) | CTSDBACE1 | |
| SCHEMBL2371340 | 0.73 | BACE1 (0.65) | CTSDBACE1BACE2 | |
| SCHEMBL15134946 | 0.73 | BACE1 (0.42) | CTSDBACE1BACE2 | |
| SCHEMBL15134947 | 0.73 | BACE1 (0.42) | CTSDBACE1BACE2 | |
| SCHEMBL2371045 | 0.73 | — | — | |
| SCHEMBL2370741 | 0.70 | OPRM1 (0.33) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547686-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115928-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |