SCHEMBL2371058

SCHEMBL2371058

COc1ccc(CCC2(N)CCCC2)cc1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.52
TSHR P16473 1/20 0.48
HRH3 Q9Y5N1 1/20 0.47
MAOB P27338 2/20 0.47
AOC3 Q16853 2/20 0.46
SIGMAR1 Q99720 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
CALM1 P0DP23 1/20 0.43
IDO1 P14902 3/20 0.43
AGXT P21549 2/20 0.43
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA5A P35218 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1820761 0.98 TSHR (0.50) TAAR1TSHRHRH3MAOBAOC3
Hydrochloric Acid SCHEMBL3964945 0.97 TSHR (0.49) TAAR1TSHRHRH3MAOBAOC3
SCHEMBL1824117 0.93 TAAR1 (0.55) TAAR1HRH3MAOBAOC3SIGMAR1
SCHEMBL1822033 0.82 MAOB (0.47) TAAR1TSHRHRH3MAOBIDO1
SCHEMBL2370366 0.81 TAAR1 (0.57) TAAR1HRH3AOC3SIGMAR1IDO1
Hydrochloric Acid SCHEMBL3966019 0.81 IDO1 (0.47) TAAR1TSHRMAOBIDO1AGXT
SCHEMBL1824988 0.81 SLC6A4 (0.46) TAAR1TSHRMAOBIDO1AGXT
Hydrochloric Acid SCHEMBL3967323 0.79 IDO1 (0.46) TAAR1TSHRMAOBIDO1AGXT
SCHEMBL639269 0.78 TSHR (0.57) TAAR1TSHRHRH3SIGMAR1SMN1; SMN2
SCHEMBL4868046 0.77 TDP1 (0.52) TAAR1TSHRMAOBIDO1AGXT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011116356-A2 POSITIVE ALLOSTERIC MODULATORS OF GROUP II MGLURS SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) 2011-09-22 WO disclosed