Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | AGXT | P21549 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2371058 | 0.81 | TAAR1 (0.52) | TAAR1HRH3SIGMAR1AOC3IDO1 | |
| SCHEMBL1820761 | 0.80 | TSHR (0.50) | TAAR1HRH3SIGMAR1AOC3IDO1 | |
| Hydrochloric Acid SCHEMBL3964945 | 0.78 | TSHR (0.49) | TAAR1HRH3SIGMAR1AOC3IDO1 | |
| SCHEMBL3163183 | 0.78 | TAAR1 (0.54) | TAAR1HRH3SIGMAR1AOC3CHRM2 | |
| SCHEMBL723511 | 0.76 | TAAR1 (0.77) | TAAR1HRH3SIGMAR1AOC3CHRM2 | |
| SCHEMBL30080050 | 0.76 | TAAR1 (0.77) | TAAR1HRH3SIGMAR1AOC3CHRM2 | |
| SCHEMBL21058245 | 0.75 | MAOA (0.52) | TAAR1 | |
| SCHEMBL29966158 | 0.74 | MTNR1A (0.48) | TAAR1HRH3SIGMAR1AOC3CHRM2 | |
| SCHEMBL29092222 | 0.74 | MTNR1A (0.48) | TAAR1HRH3SIGMAR1AOC3CHRM2 | |
| SCHEMBL1824117 | 0.74 | TAAR1 (0.55) | TAAR1HRH3SIGMAR1AOC3IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011116356-A2 | POSITIVE ALLOSTERIC MODULATORS OF GROUP II MGLURS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-22 | — | — | WO | disclosed |