Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | DUT | P33316 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TK1 | P04183 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13443477 | 0.94 | POLB (0.79) | POLBHSD17B10ALDH1A1PRKCADUT | |
| SCHEMBL25611288 | 0.91 | POLB (0.84) | POLBHSD17B10ALDH1A1PRKCADUT | |
| SCHEMBL20052005 | 0.89 | POLB (0.72) | POLBHSD17B10ALDH1A1PRKCADUT | |
| SCHEMBL14867637 | 0.86 | POLB (0.68) | POLBHSD17B10ALDH1A1PRKCADUT | |
| SCHEMBL24772316 | 0.86 | POLB (0.68) | POLBHSD17B10ALDH1A1PRKCADUT | |
| SCHEMBL23710643 | 0.86 | POLB (0.68) | POLBHSD17B10ALDH1A1PRKCADUT | |
| SCHEMBL23710592 | 0.86 | POLB (0.67) | POLBHSD17B10ALDH1A1PRKCADUT | |
| SCHEMBL25583967 | 0.85 | POLB (0.69) | POLBHSD17B10ALDH1A1PRKCADUT | |
| SCHEMBL36571379 | 0.83 | POLB (0.66) | POLBHSD17B10PRKCADUTTK1 | |
| SCHEMBL25611387 | 0.81 | POLB (0.63) | POLBHSD17B10ALDH1A1DUTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210238595-A1 | MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT | ALNYLAM PHARMACEUTICALS, INC. (US) | 2021-08-05 | — | — | US | disclosed |