SCHEMBL23711044

SCHEMBL23711044

O=C1CCC(N2Cc3cc(C4CCN(CCCCNC5CCCCC5)CC4)c(F)cc3C2=O)C(=O)N1

nearest known ligand 0.61

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ IKZF2 Q9UKS7 15/20 0.61
▸ IKZF1 Q13422 1/20 0.61
▸ CRBN Q96SW2 5/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23710930 0.99 IKZF2 (0.60) IKZF2IKZF1CRBN
SCHEMBL23710977 0.98 IKZF2 (0.62) IKZF2IKZF1CRBN
SCHEMBL23710974 0.94 IKZF2 (0.64) IKZF2IKZF1CRBN
SCHEMBL26609347 0.85 IKZF2 (0.67) IKZF2IKZF1CRBN
SCHEMBL23711087 0.85 IKZF2 (0.47) IKZF2IKZF1CRBN
SCHEMBL23711002 0.85 IKZF2 (0.47) IKZF2IKZF1CRBN
SCHEMBL27061682 0.85 IKZF2 (0.69) IKZF2IKZF1CRBN
SCHEMBL23711041 0.85 IKZF2 (0.61) IKZF2IKZF1
SCHEMBL24530849 0.84 IKZF2 (0.65) IKZF2IKZF1CRBN
SCHEMBL31144530 0.83 IKZF2 (0.69) IKZF2IKZF1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021155050-A1 KINASE MODULATORS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS BIOTHERYX, INC. (US) 2021-08-05 — — WO disclosed
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