Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 4/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2370208 | 0.95 | ALDH1A1 (0.44) | HTTALDH1A1MAPTCLK1EGFR | |
| SCHEMBL2371227 | 0.92 | APP (0.37) | HTTALDH1A1MAPTCLK1EGFR | |
| SCHEMBL2370319 | 0.80 | LMNA (0.42) | ALDH1A1MAPTCLK1LCKRXFP1 | |
| SCHEMBL2370335 | 0.80 | ALDH1A1 (0.45) | HTTALDH1A1MAPTCLK1EGFR | |
| SCHEMBL2369972 | 0.80 | PIK3CG (0.41) | ALDH1A1MAPTLCKABL1 | |
| SCHEMBL2370365 | 0.77 | ITK (0.47) | MAPTEGFRLCKAURKBLRRK2 | |
| SCHEMBL2370368 | 0.77 | ITK (0.47) | MAPTEGFRLCKAURKBLRRK2 | |
| SCHEMBL15673435 | 0.75 | LCK (0.59) | HTTALDH1A1MAPTCLK1LCK | |
| SCHEMBL29470510 | 0.75 | LCK (0.59) | HTTALDH1A1MAPTCLK1LCK | |
| SCHEMBL2399270 | 0.75 | APP (0.37) | HTTALDH1A1MAPTCLK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |