Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.54 |
| ▸ | CDK9 | P50750 | 5/20 | 0.54 |
| ▸ | CDK7 | P50613 | 15/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.53 |
| ▸ | CCNH | P51946 | 7/20 | 0.53 |
| ▸ | CDK1 | P06493 | 6/20 | 0.53 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.53 |
| ▸ | CDK4 | P11802 | 4/20 | 0.53 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.53 |
| ▸ | CDK8 | P49336 | 3/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.53 |
| ▸ | CCND1 | P24385 | 2/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.53 |
| ▸ | INSRR | P14616 | 1/20 | 0.52 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1370667 | 0.88 | CDK7 (0.66) | CDK2CDK9CDK7CCNE1CCNH | |
| SCHEMBL26696742 | 0.86 | CDK7 (0.47) | CDK2CDK9CDK7CCNE1CCNH | |
| SCHEMBL26696706 | 0.86 | CDK2 (0.53) | CDK2CDK9CDK7CCNE1CCNH | |
| SCHEMBL24962513 | 0.84 | GSK3B (0.61) | CDK2CDK9CDK7CCNE1CCNH | |
| SCHEMBL30209082 | 0.84 | GSK3B (0.61) | CDK2CDK9CDK7CCNE1CCNH | |
| SCHEMBL26696914 | 0.84 | CDK7 (0.50) | CDK2CDK9CDK7CCNE1CCNH | |
| SCHEMBL17032296 | 0.83 | CDK2 (0.58) | CDK2CDK9CDK7CCNE1CCNH | |
| SCHEMBL12143382 | 0.83 | CDK7 (0.55) | CDK2CDK9CDK7CCNE1CCNH | |
| SCHEMBL18051111 | 0.83 | KCNN3 (0.64) | CDK2CDK9CDK7CCNE1CCNH | |
| SCHEMBL13985794 | 0.82 | CDK7 (0.54) | CDK2CDK9CDK7CCNE1CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268000-B1 | PYRAZOLO[1,5-A][1,3,5]TRIAZINE AND PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS CDK INHIBITORS | AURIGENE DISCOVERY TECH LTD (IN) | 2021-08-04 | — | — | EP | disclosed |