Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2523039 | 0.71 | APP (0.34) | BACE1AHRAPP | |
| SCHEMBL2521072 | 0.71 | APP (0.34) | BACE1AHRAPP | |
| SCHEMBL1994275 | 0.68 | BACE1 (0.49) | BACE1 | |
| SCHEMBL1998989 | 0.68 | BACE1 (0.49) | BACE1 | |
| SCHEMBL1994274 | 0.68 | BACE1 (0.49) | BACE1 | |
| SCHEMBL1999573 | 0.67 | CYP11B1 (0.43) | BACE1 | |
| SCHEMBL2519390 | 0.66 | BACE1 (0.54) | BACE1 | |
| SCHEMBL2519394 | 0.66 | BACE1 (0.54) | BACE1 | |
| SCHEMBL12212386 | 0.65 | BACE1 (0.30) | BACE1 | |
| SCHEMBL2370741 | 0.65 | OPRM1 (0.33) | BACE1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547685-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | Amgen Inc. (US) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |