Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22369248 | 0.74 | EPHX1 (0.39) | EPHX1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL12883924 | 0.72 | EPHX1 (0.38) | EPHX1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL31597078 | 0.71 | EPHX1 (0.38) | EPHX1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL17176084 | 0.70 | USP2 (0.51) | USP2CYP1A2CYP2C9CYP2D6ALDH1A1 | |
| SCHEMBL20312244 | 0.69 | CYP2C9 (0.40) | EPHX1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL20993453 | 0.67 | EPHX1 (0.45) | EPHX1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL29589464 | 0.67 | EPHX1 (0.45) | EPHX1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL6495220 | 0.67 | EPHX1 (0.45) | EPHX1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL771850 | 0.67 | GAA (0.53) | EPHX1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL12254227 | 0.67 | CYP2C9 (0.54) | USP2CYP1A2CYP2C9CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230145003-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-05-11 | — | — | US | disclosed |
| WO-2021155320-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230145003-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | EPHX1 2507/4885CHRNB2 3146/4885CHRNA4 3801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.