SCHEMBL2371469

SCHEMBL2371469

COc1ccc(C2(c3ccc(OCCO)cc3)C=Cc3c4c(c5ccccc5c3O2)-c2ccccc2C4(C)C)cc1

nearest known ligand 0.32

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 1/20 0.32
HTT P42858 1/20 0.32
GPR84 Q9NQS5 1/20 0.32
PDK2 Q15119 2/20 0.31
CHRNB4 P30926 1/20 0.31
CHRNA3 P32297 1/20 0.31
CHRNA7 P36544 1/20 0.31
RECQL P46063 1/20 0.30
HTR1A P08908 1/20 0.30
DRD2 P14416 1/20 0.30
HTR7 P34969 1/20 0.30
HTR6 P50406 1/20 0.30
NR1I2 O75469 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13988190 0.95 ALK (0.33) ALKPDK2CHRNB4CHRNA3CHRNA7
SCHEMBL8510608 0.94 MEN1 (0.32) ALKHTTGPR84PDK2RECQL
SCHEMBL15214880 0.93 CHRNB4 (0.32) ALKPDK2CHRNB4CHRNA3CHRNA7
SCHEMBL13988163 0.92 PDK2 (0.32) ALKPDK2CHRNB4CHRNA3CHRNA7
SCHEMBL13988246 0.92 ALK (0.40) ALKGPR84PDK2
SCHEMBL29664189 0.92 RECQL (0.33) HTTPDK2RECQL
SCHEMBL9929431 0.92 RECQL (0.33) HTTPDK2RECQL
SCHEMBL30708919 0.92 MEN1 (0.31) ALKHTTPDK2RECQL
SCHEMBL1823143 0.92 ALK (0.35) ALKGPR84PDK2
SCHEMBL3704719 0.92 MEN1 (0.31) ALKHTTPDK2RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2545095-B1 METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES, NON-AQUEOUS DISPERSIONS THEREOF AND ARTICLES PREPARED THEREWITH TRANSITIONS OPTICAL INC (US) 2024-01-24 EP disclosed
EP-2545140-B1 METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES TRANSITIONS OPTICAL INC (US) 2017-06-21 EP disclosed
US-8647538-B2 Photochromic compounds having at least two photochromic moieties TRANSITIONS OPTICAL, INC. (US) 2014-02-11 US disclosed
US-8563213-B2 Methods for producing photosensitive microparticles TRANSITIONS OPTICAL, INC. (US) 2013-10-22 US disclosed
US-8563212-B2 Methods for producing photosensitive microparticles, non-aqueous dispersions thereof and articles prepared therewith TRANSITIONS OPTICAL, INC. (US) 2013-10-22 US disclosed
EP-2545140-A1 METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES Transitions Optical, Inc. (US) 2013-01-16 EP disclosed
EP-2545095-A1 METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES, NON-AQUEOUS DISPERSIONS THEREOF AND ARTICLES PREPARED THEREWITH Transitions Optical, Inc. (US) 2013-01-16 EP disclosed
US-20120136148-A1 Photochromic Compounds Having At Least Two Photochromic Moieties TRANSITIONS OPTICAL, INC. (US) 2012-05-31 US disclosed
WO-2011112327-A1 METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES TRANSITIONS OPTICAL, INC. (US) 2011-09-15 WO disclosed
WO-2011112325-A1 METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES, NON-AQUEOUS DISPERSIONS THEREOF AND ARTICLES PREPARED THEREWITH TRANSITIONS OPTICAL, INC. (US) 2011-09-15 WO disclosed
US-20100221661-A1 METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES TRANSITIONS OPTICAL, INC. (US) 2010-09-02 US disclosed
US-20100209697-A1 METHODS FOR PRODUCING PHOTOSENSITIVE MICROPARTICLES, NON-AQUEOUS DISPERSIONS THEREOF AND ARTICLES PREPARED THEREWITH TRANSITIONS OPTICAL, INC. (US) 2010-08-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120136148-A1 Photochromic Compounds Having At Least Two Photochromic Moieties CRY2, PCNA, MTCL3 ALK 3290/4885HTT 149/4885GPR84 4837/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.