Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.35 |
| ▸ | CTSD | P07339 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 5/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23704964 | 0.81 | BACE1 (0.35) | BACE1CTSDAPPKDM1ACMA1 | |
| SCHEMBL24275639 | 0.79 | BACE1 (0.49) | BACE1CTSDAPPBACE2KDM1A | |
| SCHEMBL23704986 | 0.77 | BACE1 (0.41) | BACE1LMNAMAPTHTTBLM | |
| SCHEMBL23704877 | 0.75 | BACE1 (0.39) | BACE1CTSDAPPKDM1ATDP2 | |
| SCHEMBL17802106 | 0.70 | SLC6A4 (0.34) | BACE1APPKDM1ACMA1AHR | |
| SCHEMBL23704862 | 0.68 | BACE1 (0.35) | BACE1APPKDM1ATDP2LMNA | |
| SCHEMBL23715375 | 0.68 | BACE1 (0.33) | BACE1CTSDAPPBACE2CMA1 | |
| SCHEMBL31367719 | 0.67 | BACE1 (0.40) | BACE1APPKDM1ACMA1AHR | |
| SCHEMBL23705009 | 0.67 | BACE1 (0.37) | BACE1CTSDAPPKDM1ACMA1 | |
| SCHEMBL23705015 | 0.67 | BACE1 (0.35) | BACE1KDM1ACMA1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155316-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |