SCHEMBL31367719

SCHEMBL31367719

Brc1ccc2c(c1)C1(CC1)COC2

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 12/20 0.40
KDM1A O60341 1/20 0.38
APP P05067 3/20 0.34
CMA1 P23946 1/20 0.33
AHR P35869 1/20 0.33
TDP2 O95551 1/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
HTT P42858 1/20 0.32
BLM P54132 1/20 0.32
PNMT P11086 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23704976 0.91 BACE1 (0.40) BACE1KDM1AAPPCMA1AHR
SCHEMBL19827950 0.78 KDM1A (0.38) KDM1AMAPT
SCHEMBL23705009 0.77 BACE1 (0.37) BACE1KDM1AAPPCMA1AHR
SCHEMBL23704964 0.75 BACE1 (0.35) BACE1KDM1AAPPCMA1AHR
SCHEMBL23704862 0.75 BACE1 (0.35) BACE1KDM1AAPPTDP2LMNA
SCHEMBL29793198 0.75 SIGMAR1 (0.33) KDM1A
SCHEMBL19828185 0.75 SIGMAR1 (0.33) KDM1A
SCHEMBL23705015 0.74 BACE1 (0.35) BACE1KDM1ACMA1AHR
SCHEMBL23705803 0.73 BACE1 (0.34) BACE1KDM1ACMA1AHRPNMT
SCHEMBL23706166 0.73 PNMT (0.36) BACE1KDM1ACMA1AHRPNMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250206759-A1 FUSED RING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE OF FUSED RING COMPOUND CHENGDU HYPERWAY PHARMACEUTICALS CO., LTD. (CN) 2025-06-26 US disclosed
EP-4509507-A1 FUSED RING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE OF FUSED RING COMPOUND Chengdu Hyperway Pharmaceuticals Co., Ltd. (CN) 2025-02-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250206759-A1 FUSED RING COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE OF FUSED RING COMPOUND KRAS, NRAS, HRAS BACE1 430/4885KDM1A 4278/4885APP 339/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.