Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 15/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 8/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | CCR3 | P51677 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23715847 | 0.73 | S1PR3 (0.42) | S1PR3S1PR4S1PR1S1PR5S1PR2 | |
| SCHEMBL23715831 | 0.71 | S1PR3 (0.47) | S1PR3S1PR4S1PR1S1PR5S1PR2 | |
| SCHEMBL23716419 | 0.70 | SLC6A3 (0.35) | KCNH2 | |
| SCHEMBL23715838 | 0.69 | S1PR3 (0.45) | S1PR3S1PR4S1PR1S1PR5S1PR2 | |
| SCHEMBL23716190 | 0.68 | SLC6A3 (0.41) | NPSR1 | |
| SCHEMBL17663846 | 0.67 | S1PR3 (0.61) | S1PR3S1PR4S1PR1S1PR5S1PR2 | |
| SCHEMBL23716102 | 0.65 | S1PR3 (0.40) | S1PR3S1PR4S1PR1S1PR5S1PR2 | |
| SCHEMBL23715998 | 0.64 | S1PR3 (0.42) | S1PR3S1PR4S1PR1S1PR5S1PR2 | |
| SCHEMBL23715785 | 0.62 | S1PR3 (0.48) | S1PR3S1PR4S1PR1S1PR5CYP3A4 | |
| SCHEMBL17663806 | 0.61 | NPC1 (0.45) | S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209732-B1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | SCRIPPS RESEARCH INST (US) | 2021-08-04 | — | — | EP | disclosed |