Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.48 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30818638 | 0.78 | HPGD (0.56) | HPGDGPR139POLBHTTKMT2A | |
| SCHEMBL6161768 | 0.76 | NPC1 (0.49) | HPGDGPR139POLBHTTNPC1 | |
| SCHEMBL5866425 | 0.76 | NPC1 (0.49) | HPGDGPR139POLBHTTNPC1 | |
| SCHEMBL7287608 | 0.76 | CYP1A2 (0.44) | GPR139KMT2AKDM4EPKMCYP1A2 | |
| SCHEMBL16464365 | 0.75 | P2RX7 (0.67) | HPGDGPR139POLBHTTKMT2A | |
| SCHEMBL17663873 | 0.74 | S1PR3 (0.67) | HPGDGPR139S1PR3S1PR2S1PR4 | |
| SCHEMBL6838166 | 0.74 | HPGD (0.51) | HPGDGPR139POLBHTTKMT2A | |
| SCHEMBL6280523 | 0.74 | MTNR1A (0.51) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL27920895 | 0.74 | EPHX2 (0.80) | HPGDPOLBHTTKMT2AMEN1 | |
| SCHEMBL5109834 | 0.73 | TACR1 (0.42) | HPGDGPR139POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209732-B1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | SCRIPPS RESEARCH INST (US) | 2021-08-04 | — | — | EP | disclosed |