Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473677 | 0.83 | SNCA (0.34) | DGAT1IRAK4BRD4CREBBP | |
| SCHEMBL1564459 | 0.82 | DGAT1 (0.37) | DGAT1ALPLPDGFRBKDRAAK1 | |
| SCHEMBL30531492 | 0.82 | IRAK4 (0.39) | DGAT1IRAK4 | |
| SCHEMBL8247537 | 0.82 | IRAK4 (0.39) | DGAT1IRAK4 | |
| SCHEMBL3304410 | 0.81 | GSK3A (0.34) | DGAT1IRAK4PDGFRBKDRAAK1 | |
| SCHEMBL20604761 | 0.80 | LPL (0.35) | DGAT1IRAK4 | |
| SCHEMBL29600164 | 0.79 | BRD4 (0.43) | DGAT1PDGFRBKDRAAK1BRD4 | |
| SCHEMBL15183831 | 0.79 | BRD4 (0.43) | DGAT1PDGFRBKDRAAK1BRD4 | |
| SCHEMBL797478 | 0.77 | DGAT1 (0.41) | DGAT1GRIN2B | |
| SCHEMBL30451160 | 0.77 | DGAT1 (0.41) | DGAT1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551610-B1 | BICYCLO[1.1.1]PENTANE INHIBITORS OF DUAL LEUCINE ZIPPER (DLK) KINASE FOR THE TREATMENT OF DISEASE | UNIV TEXAS (US) | 2021-08-11 | — | — | EP | disclosed |