SCHEMBL23716778

SCHEMBL23716778

N#CCN(C(=O)c1ccccc1)c1cccc(C(=O)Nc2c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2C(F)(F)F)c1F

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
POLQ O75417 1/20 0.38
KCNK3 O14649 2/20 0.35
KCNK9 Q9NPC2 2/20 0.35
GPBAR1 Q8TDU6 3/20 0.34
MEN1 O00255 1/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.32
RXFP1 Q9HBX9 4/20 0.31
PTGES O14684 3/20 0.31
HDAC8 Q9BY41 1/20 0.31
EPHX1 P07099 1/20 0.31
MLYCD O95822 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30266971 0.94 GPBAR1 (0.35) POLQKCNK3KCNK9GPBAR1MEN1
SCHEMBL23716797 0.94 GPBAR1 (0.35) POLQKCNK3KCNK9GPBAR1MEN1
SCHEMBL24914497 0.92 POLQ (0.38) POLQKCNK3KCNK9MEN1LMNA
SCHEMBL21563473 0.91 GPBAR1 (0.38) POLQKCNK3KCNK9GPBAR1MAPT
SCHEMBL23716450 0.90 GPBAR1 (0.33) POLQGPBAR1RXFP1MLYCD
SCHEMBL21563800 0.90 GPBAR1 (0.34) POLQKCNK3KCNK9GPBAR1MEN1
SCHEMBL23059630 0.89 GPBAR1 (0.33) POLQGPBAR1PTGES
SCHEMBL31679336 0.89 TSHR (0.38) KCNK3KCNK9MEN1LMNAMAPT
SCHEMBL23716929 0.89 SMN1; SMN2 (0.36) POLQGPBAR1MEN1LMNAMAPT
SCHEMBL28621340 0.89 TSHR (0.38) KCNK3KCNK9MEN1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210238126-A1 Benzamide Compound and Use Thereof METISA BIOTECHNOLOGY CO.,LTD. (CN) 2021-08-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210238126-A1 Benzamide Compound and Use Thereof TMBIM6, BCHE, DDT POLQ 4771/4885KCNK3 1286/4885KCNK9 1042/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.