SCHEMBL23716929

SCHEMBL23716929

N#CCN(C(=O)c1ccc(C(F)(F)F)cc1)c1cccc(C(=O)Nc2c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2Br)c1F

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.36
GPBAR1 Q8TDU6 4/20 0.35
RXFP1 Q9HBX9 4/20 0.35
POLQ O75417 1/20 0.34
HDAC6 Q9UBN7 3/20 0.34
MAPT P10636 2/20 0.34
HDAC11 Q96DB2 2/20 0.34
HDAC8 Q9BY41 2/20 0.34
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34
LMNA P02545 1/20 0.34
RAB9A P51151 1/20 0.34
KMT2A Q03164 1/20 0.34
PPARG P37231 2/20 0.33
PPARD Q03181 2/20 0.33
PPARA Q07869 2/20 0.33
NR1H4 Q96RI1 2/20 0.33
XBP1 P17861 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
P2RX1 P51575 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23716797 0.93 GPBAR1 (0.35) SMN1; SMN2GPBAR1RXFP1POLQMEN1
SCHEMBL30266971 0.93 GPBAR1 (0.35) SMN1; SMN2GPBAR1RXFP1POLQMEN1
SCHEMBL23716778 0.89 POLQ (0.38) SMN1; SMN2GPBAR1RXFP1POLQMAPT
SCHEMBL23059689 0.89 GPBAR1 (0.36) GPBAR1P2RX7
SCHEMBL23059714 0.89 GPBAR1 (0.34) GPBAR1P2RX7
SCHEMBL21563473 0.88 GPBAR1 (0.38) GPBAR1POLQMAPTP2RX1
SCHEMBL21563800 0.88 GPBAR1 (0.34) GPBAR1POLQMAPTMEN1LMNA
SCHEMBL23716450 0.88 GPBAR1 (0.33) GPBAR1RXFP1POLQ
SCHEMBL23059630 0.85 GPBAR1 (0.33) GPBAR1POLQ
SCHEMBL23059629 0.85 GPBAR1 (0.34) GPBAR1POLQP2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210238126-A1 Benzamide Compound and Use Thereof METISA BIOTECHNOLOGY CO.,LTD. (CN) 2021-08-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210238126-A1 Benzamide Compound and Use Thereof TMBIM6, BCHE, DDT SMN1; SMN2 1111/4885GPBAR1 1655/4885RXFP1 3251/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.