SCHEMBL2371775

SCHEMBL2371775

[CH2]NS(=O)(=O)c1ccc(Br)cc1C(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PFKFB3 Q16875 1/20 0.46
SLC22A12 Q96S37 3/20 0.42
PPARG P37231 1/20 0.41
FFAR1 O14842 1/20 0.40
FFAR4 Q5NUL3 1/20 0.40
CNR2 P34972 8/20 0.40
CNR1 P21554 5/20 0.38
ALPL P05186 1/20 0.38
KDM1A O60341 2/20 0.37
TRPV4 Q9HBA0 1/20 0.36
CA1 P00915 2/20 0.36
CA2 P00918 2/20 0.36
CA5A P35218 1/20 0.36
CA9 Q16790 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2371777 0.83 PFKFB3 (0.46) PFKFB3SLC22A12PPARGFFAR1FFAR4
SCHEMBL14995856 0.82 PFKFB3 (0.46) PFKFB3SLC22A12PPARGFFAR1FFAR4
SCHEMBL3013193 0.80 PFKFB3 (0.44) PFKFB3SLC22A12PPARGFFAR1FFAR4
SCHEMBL3017636 0.80 GLA (0.55) PFKFB3CNR2CNR1CA1CA2
SCHEMBL2372635 0.80 PFKFB3 (0.49) PFKFB3SLC22A12PPARGFFAR1FFAR4
SCHEMBL2372639 0.78 CNR2 (0.48) PFKFB3CNR2CNR1
SCHEMBL695564 0.77 TRPV4 (0.58) PFKFB3SLC22A12PPARGFFAR1FFAR4
SCHEMBL30945237 0.77 PFKFB3 (0.41) PFKFB3SLC22A12PPARGFFAR1FFAR4
SCHEMBL10296146 0.77 PFKFB3 (0.41) PFKFB3SLC22A12PPARGFFAR1FFAR4
SCHEMBL709661 0.77 PFKFB3 (0.41) PFKFB3SLC22A12PPARGFFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP claimed
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 US claimed
WO-2011113861-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 WO claimed
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP disclosed
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 US disclosed
WO-2011113861-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS STS, ARSA, TST PFKFB3 1747/4885SLC22A12 1883/4885PPARG 906/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.