SCHEMBL2371994

SCHEMBL2371994

CNS(=O)(=O)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.68
NR3C2 P08235 1/20 0.59
CA1 P00915 3/20 0.57
CA2 P00918 3/20 0.57
SMN1; SMN2 Q16637 2/20 0.57
GAA P10253 1/20 0.57
KIF11 P52732 2/20 0.56
CA12 O43570 2/20 0.55
CA3 P07451 2/20 0.55
CA4 P22748 2/20 0.55
CA6 P23280 2/20 0.55
CA5A P35218 2/20 0.55
CA7 P43166 2/20 0.55
CA9 Q16790 2/20 0.55
CA13 Q8N1Q1 2/20 0.55
CA14 Q9ULX7 2/20 0.55
CA5B Q9Y2D0 2/20 0.55
LMNA P02545 1/20 0.53
HTT P42858 1/20 0.53
MMP1 P03956 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22635666 0.91 ALDH1A1 (0.58) ALDH1A1NR3C2CA1CA2SMN1; SMN2
SCHEMBL27170892 0.89 SMN1; SMN2 (0.73) ALDH1A1NR3C2CA1CA2SMN1; SMN2
SCHEMBL4002880 0.85 MAPT (0.68) CA1CA2SMN1; SMN2GAACA12
SCHEMBL13588309 0.83 CA1 (0.56) CA1CA2SMN1; SMN2KIF11CA12
SCHEMBL7629070 0.82 SMN1; SMN2 (0.80) ALDH1A1NR3C2CA1CA2SMN1; SMN2
SCHEMBL8483992 0.81 ALDH1A1 (1.00) ALDH1A1NR3C2CA1CA2SMN1; SMN2
SCHEMBL24361297 0.80 CA1 (0.54) ALDH1A1CA1CA2KIF11MMP1
SCHEMBL15946356 0.80 ALDH1A1 (0.56) ALDH1A1CA1CA2SMN1; SMN2KIF11
SCHEMBL12054697 0.79 CA1 (0.53) CA1CA2SMN1; SMN2KIF11CA12
SCHEMBL22446711 0.79 CA1 (0.53) CA1CA2SMN1; SMN2KIF11CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2547204-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS Bayer Intellectual Property GmbH (DE) 2013-01-23 EP claimed
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 US claimed
WO-2011113861-A2 ARYL AND HETARYL SULFONAMIDES AS ACTIVE AGENTS AGAINST ABIOTIC PLANT STRESS BAYER CROPSCIENCE AG (DE) 2011-09-22 WO claimed
US-20250236616-A1 IMMUNOMODULATING AZALIDES ZOETIS SERVICES LLC 2025-07-24 US disclosed
CN-118223046-A Electrochemical preparation method of oxazoline compound containing sulfonamide group 华南理工大学 2024-06-21 CN disclosed
WO-2023177877-A1 RALINEPAG PRODRUGS AND USES THEREOF UNITED THERAPEUTICS CORPORATION (US) 2023-09-21 WO disclosed
WO-2023086417-A1 COMPOUNDS AND METHODS OF USE THEREOF ALGEN BIOTECHNOLOGIES, INC. (US) 2023-05-19 WO disclosed
CN-110857278-B Method for synthesizing N-methylsulfonamide in water 南京理工大学 2022-04-15 CN disclosed
CN-109420525-B Metal iridium catalyst of 2, 2' -bis-benzimidazole ligand and method for synthesizing N-methylated primary amine by using metal iridium catalyst 南京理工大学 2021-10-08 CN disclosed
CN-108707096-B Process for preparing aminoalcohol derivatives 上海科技大学 2021-03-19 CN disclosed
WO-2020182159-A1 JAK KINASE INHIBITOR, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF IN FIELD OF MEDICINE 上海华汇拓医药科技有限公司 2020-09-17 WO disclosed
EP-1889848-A1 6,7-UNSATURATED-7-CARBAMOYL SUBSTITUTED MORPHINAN DERIVATIVE Shionogi Co., Ltd. (JP) 2008-02-20 EP disclosed
WO-2007122173-A1 SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE JANSSEN PHARMACEUTICA N.V. (BE) 2007-11-01 WO disclosed
CN-1208329-C Novel aniline derivative HOFFMANN LA ROCHE (CH) 2005-06-29 CN disclosed
EP-1521746-A1 QUINAZOLINONE MODULATORS OF NUCLEAR RECEPTORS X-Ceptor Therapeutics, Inc. (US) 2005-04-13 EP disclosed
CN-1604890-A Substituted cyclohexane derivatives HOFFMANN LA ROCHE (CH) 2005-04-06 CN disclosed
EP-1456171-A1 SUBSTITUTED CYCLOHEXANE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2004-09-15 EP disclosed
WO-2003076418-A1 QUINAZOLINONE MODULATORS OF NUCLEAR RECEPTORS X-CEPTOR THERAPEUTICS, INC. (US) 2003-09-18 WO disclosed
CN-1443179-A Aniline derivatives HOFFMANN LA ROCHE (CH) 2003-09-17 CN disclosed
WO-2003053919-A1 SUBSTITUTED CYCLOHEXANE DERIVATIVES F. HOFFMANN-LA-ROCHE AG (CH) 2003-07-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250236616-A1 IMMUNOMODULATING AZALIDES IL2, MALT1, FCGRT ALDH1A1 196/4885NR3C2 122/4885CA1 1803/4885
US-20110230350-A1 ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS STS, ARSA, TST ALDH1A1 1980/4885NR3C2 634/4885CA1 4599/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.