Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13163277 | 0.77 | LMNA (0.49) | KDM4EALDH1A1HPGDTP53GAA | |
| SCHEMBL30283684 | 0.74 | KDM4E (0.49) | KDM4ETSHRALDH1A1HPGDHSD17B10 | |
| SCHEMBL29576662 | 0.72 | EGFR (0.46) | TSHRALDH1A1TP53SMN1; SMN2HSD17B10 | |
| SCHEMBL21176839 | 0.72 | EGFR (0.46) | TSHRALDH1A1TP53SMN1; SMN2HSD17B10 | |
| SCHEMBL14966643 | 0.72 | MET (0.47) | TSHR | |
| SCHEMBL29410952 | 0.71 | KDM4E (0.63) | KDM4EALDH1A1CASP1CASP7L3MBTL1 | |
| SCHEMBL238581 | 0.71 | MAPK9 (0.43) | ALDH1A1HPGDTP53SMN1; SMN2PI4K2A | |
| SCHEMBL22119902 | 0.71 | KDM4E (0.57) | KDM4EALDH1A1HPGDTP53GAA | |
| SCHEMBL31214763 | 0.70 | KDM4E (0.61) | KDM4EL3MBTL1MAPTLMNAAURKA | |
| SCHEMBL30639545 | 0.70 | KDM4E (0.61) | KDM4EALDH1A1GAAL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | claimed |