Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 18/20 | 0.59 |
| ▸ | HTR2A | P28223 | 15/20 | 0.57 |
| ▸ | HTR1A | P08908 | 12/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19019006 | 0.93 | DRD2 (0.55) | DRD2HTR2AHTR1ADRD1DRD4 | |
| SCHEMBL19018993 | 0.81 | DRD2 (0.54) | DRD2HTR2AHTR1ADRD1DRD4 | |
| SCHEMBL19018842 | 0.80 | DRD2 (0.54) | DRD2HTR2AHTR1ADRD1DRD4 | |
| SCHEMBL22417544 | 0.80 | DRD2 (0.49) | DRD2HTR2AHTR1ADRD1DRD4 | |
| SCHEMBL17677711 | 0.80 | HTR1A (0.53) | DRD2HTR2AHTR1ADRD1DRD4 | |
| SCHEMBL22417310 | 0.80 | DRD2 (0.47) | DRD2HTR2AHTR1ADRD1DRD4 | |
| SCHEMBL22417534 | 0.79 | DRD2 (0.54) | DRD2HTR2AHTR1ADRD1DRD4 | |
| SCHEMBL22417545 | 0.79 | DRD2 (0.54) | DRD2HTR2AHTR1ADRD1DRD4 | |
| SCHEMBL12930984 | 0.78 | DRD3 (0.60) | DRD2HTR2AHTR1ADRD1DRD4 | |
| SCHEMBL1055026 | 0.78 | DRD3 (0.60) | DRD2HTR2AHTR1ADRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445502-B2 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHOLOGICAL DISORDERS | ALKERMES PHARMA IRELAND LTD (IE) | 2022-09-28 | — | — | EP | disclosed |
| EP-2445343-B1 | PRODRUGS OF NH-ACIDIC COMPOUNDS | ALKERMES PHARMA IRELAND LTD (IE) | 2021-08-04 | — | — | EP | disclosed |