Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | BLM | P54132 | 2/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | MPO | P05164 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | DPP4 | P27487 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL2323821 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL5062089 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL2723276 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL28152577 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL1839831 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL23931432 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL1839832 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL6839093 | 0.96 | KMT2A (0.64) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL23924434 | 0.96 | KMT2A (0.64) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL4395543 | 0.96 | KDM4E (0.64) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240076717-A1 | METHODS AND COMPOSITIONS FOR SELECTIVE CLEAVAGE OF NUCLEIC ACIDS WITH RECOMBINANT NUCLEASES | ILLUMINA, INC. | 2024-03-07 | — | — | US | disclosed |
| US-11773427-B2 | Methods and compositions for selective cleavage of nucleic acids with recombinant nucleases | ILLUMINA, INC. (US) | 2023-10-03 | — | — | US | disclosed |
| US-20230167510-A1 | UNIVERSAL PRIMERS FOR DETECTION OF BACTERIA, FUNGI AND EUKARYOTIC MICROORGANISMS | UNITED STATES GOVERNMENT | 2023-06-01 | — | — | US | disclosed |
| US-20230159986-A1 | METHODS FOR DETECTING AND SEQUENCING A TARGET NUCLEIC ACID | UNITED STATES GOVERNMENT | 2023-05-25 | — | — | US | disclosed |
| US-20210324444-A1 | METHODS AND COMPOSITIONS FOR SELECTIVE CLEAVAGE OF NUCLEIC ACIDS WITH RECOMBINANT NUCLEASES | ILLUMINA, INC. | 2021-10-21 | — | — | US | disclosed |
| US-20210246519-A1 | SPIKED PRIMERS FOR ENRICHMENT OF PATHOGEN NUCLEIC ACIDS AMONG BACKGROUND OF NUCLEIC ACIDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2021-08-12 | — | — | US | disclosed |