Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | BLM | P54132 | 2/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.64 |
| ▸ | MPO | P05164 | 1/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Tryptophan SCHEMBL23924434 | 1.00 | KMT2A (0.64) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL5062089 | 0.96 | KDM4E (0.70) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL2323821 | 0.96 | KDM4E (0.70) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL28152577 | 0.96 | KDM4E (0.70) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL23722672 | 0.96 | KDM4E (0.70) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL2723276 | 0.96 | KDM4E (0.70) | KMT2AKDM4EMAPTMEN1LMNA | |
| Tryptophan SCHEMBL1839832 | 0.96 | KDM4E (0.70) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL23931432 | 0.96 | KDM4E (0.70) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL1839831 | 0.96 | KDM4E (0.70) | KMT2AKDM4EMAPTMEN1LMNA | |
| Dl-Tryptophan SCHEMBL29015084 | 0.95 | KDM4E (0.58) | KMT2AKDM4EMAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2756076-B1 | ENZYME VARIANTS WITH IMPROVED PROPERTIES | METGEN OY (FI) | 2017-04-26 | — | — | EP | claimed |
| US-20170081643-A1 | LACCASE VARIANTS HAVING INCREASED ACTIVITY IN ALKALINE CONDITIONS | METGEN OY (FI) | 2017-03-23 | — | — | US | claimed |
| EP-2756076-A1 | ENZYME VARIANTS WITH IMPROVED PROPERTIES | MetGen Oy (FI) | 2014-07-23 | — | — | EP | claimed |
| WO-2013038062-A1 | ENZYME VARIANTS WITH IMPROVED PROPERTIES | METGEN OY (FI) | 2013-03-21 | — | — | WO | claimed |
| EP-2756076-B1 | ENZYME VARIANTS WITH IMPROVED PROPERTIES | METGEN OY (FI) | 2017-04-26 | — | — | EP | disclosed |
| US-20170081643-A1 | LACCASE VARIANTS HAVING INCREASED ACTIVITY IN ALKALINE CONDITIONS | METGEN OY (FI) | 2017-03-23 | — | — | US | disclosed |
| US-20150159144-A1 | ENZYME VARIANTS WITH IMPROVED PROPERTIES | METGEN OY (FI) | 2015-06-11 | — | — | US | disclosed |
| EP-2756076-A1 | ENZYME VARIANTS WITH IMPROVED PROPERTIES | MetGen Oy (FI) | 2014-07-23 | — | — | EP | disclosed |
| WO-2013038062-A1 | ENZYME VARIANTS WITH IMPROVED PROPERTIES | METGEN OY (FI) | 2013-03-21 | — | — | WO | disclosed |
| US-20040191911-A1 | Method for altering degradation of engineered protein in plant cells | NELSON RICHARD S (US) | 2004-09-30 | — | — | US | disclosed |
| EP-1309708-A2 | METHOD FOR ALTERING DEGRADATION OF ENGINEERED PROTEIN IN PLANT CELLS | THE SAMUEL ROBERTS NOBLE FOUNDATION, INC. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002006501-A2 | METHOD FOR ALTERING DEGRADATION OF ENGINEERED PROTEIN IN PLANT CELLS | THE SAMUEL ROBERTS NOBLE FOUNDATION, INC. (US) | 2002-01-24 | — | — | WO | disclosed |