Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | BLM | P54132 | 2/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | MPO | P05164 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | DPP4 | P27487 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL2323821 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL2723276 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL28152577 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL23722672 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL1839831 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL23931432 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL1839832 | 1.00 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL6839093 | 0.96 | KMT2A (0.64) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL23924434 | 0.96 | KMT2A (0.64) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL4395543 | 0.96 | KDM4E (0.64) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118215744-A | Target enrichment and quantification using isothermal linear amplification probes | 费城儿童医院 | 2024-06-18 | — | — | CN | disclosed |
| CN-112888791-A | Identification and analysis of microbial samples by rapid incubation and nucleic acid enrichment | 伊鲁米那股份有限公司 | 2021-06-01 | — | — | CN | disclosed |
| CN-111065746-A | Methods and compositions for selective cleavage of nucleic acids with recombinant nucleases | 伊鲁米纳公司 | 2020-04-24 | — | — | CN | disclosed |
| US-7323301-B2 | Medical diagnosis using chromosomes, nucleic acids | NAGASAKI UNIVERSITY (JP) | 2008-01-29 | — | — | US | disclosed |
| US-20030162203-A1 | Medical diagnosis using chromosomes, nucleic acids | NAGASAKI UNIVERSITY (JP) | 2003-08-28 | — | — | US | disclosed |
| EP-1321533-A2 | Nucleic acid, probe comprising the nucleic acid and screening method using the probe | Nagasaki University (JP) | 2003-06-25 | — | — | EP | disclosed |