Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.33 |
| ▸ | PDXK | O00764 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20862093 | 0.81 | CYP3A4 (0.37) | CYP3A4CHRM1ALOX15MAOATBXA2R | |
| SCHEMBL30012993 | 0.81 | CYP3A4 (0.37) | CYP3A4CHRM1ALOX15MAOATBXA2R | |
| SCHEMBL14818690 | 0.81 | KDM4E (0.36) | CYP3A4CHRM1ALOX15MAOATBXA2R | |
| SCHEMBL9455975 | 0.77 | AXL (0.42) | CYP3A4CHRM1ALOX15MAOATBXA2R | |
| SCHEMBL9656230 | 0.77 | KDM4E (0.45) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL23743789 | 0.75 | CCR1 (0.41) | CYP3A4CHRM1ALOX15MAOATBXA2R | |
| SCHEMBL9332858 | 0.75 | ALDH1A1 (0.39) | ALDH1A1KDM4EHPGDHSD17B10LMNA | |
| SCHEMBL23723621 | 0.74 | KCNJ5 (0.33) | CYP3A4CHRM1ALOX15MAOATBXA2R | |
| SCHEMBL10861616 | 0.73 | CYP3A4 (0.33) | CYP3A4CHRM1ALOX15MAOATBXA2R | |
| SCHEMBL26281206 | 0.73 | PDXK (0.42) | CYP3A4CHRM1ALOX15MAOATBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100124-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Janssen Biotech, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| CN-115427109-A | Heterocyclic compounds as dihydroorotate dehydrogenase inhibitors | 詹森生物科技公司 | 2022-12-02 | — | — | CN | disclosed |
| WO-2021156787-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
| WO-2021156787-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2021-08-12 | — | — | WO | disclosed |