Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1317647 | 0.87 | DGAT1 (0.55) | DGAT1PARP1HDAC1HDAC6KDM4E | |
| SCHEMBL2039681 | 0.84 | KDM4E (0.41) | DGAT1HDAC1HDAC6KDM4EMEN1 | |
| SCHEMBL24252415 | 0.82 | DGAT1 (0.39) | DGAT1HDAC1HDAC6KDM4EMEN1 | |
| SCHEMBL4047607 | 0.82 | DGAT1 (0.50) | DGAT1PARP1HDAC1HDAC6KDM4E | |
| SCHEMBL147636 | 0.79 | CES2 (0.39) | DGAT1PARP1HDAC1KMT2AMAP2K1 | |
| SCHEMBL24619347 | 0.78 | DGAT1 (0.47) | DGAT1PARP1MEN1MAPTKMT2A | |
| SCHEMBL29925464 | 0.78 | DGAT1 (0.47) | DGAT1PARP1MEN1MAPTKMT2A | |
| SCHEMBL1725337 | 0.78 | DGAT1 (0.47) | DGAT1PARP1HDAC1HDAC6MEN1 | |
| SCHEMBL16637069 | 0.78 | NOTUM (0.41) | DGAT1KDM4EMAPTGLAIKBKB | |
| SCHEMBL8048802 | 0.76 | NMT1 (0.35) | DGAT1PARP1KDM4EGLAGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4724436-A1 | COMPOUNDS AND METHODS FOR MODULATING SPLICING | Remix Therapeutics Inc. (US) | 2026-04-15 | — | — | EP | disclosed |
| WO-2024259017-A1 | COMPOUNDS AND METHODS FOR MODULATING SPLICING | REMIX THERAPEUTICS INC. (US) | 2024-12-19 | — | — | WO | disclosed |
| CN-116113632-A | Heterocyclic derivative, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2023-05-12 | — | — | CN | disclosed |
| EP-4100124-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Janssen Biotech, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| CN-115427109-A | Heterocyclic compounds as dihydroorotate dehydrogenase inhibitors | 詹森生物科技公司 | 2022-12-02 | — | — | CN | disclosed |
| WO-2022206723-A1 | HETEROCYCLIC DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | 浙江海正药业股份有限公司 | 2022-10-06 | — | — | WO | disclosed |
| WO-2021156787-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
| WO-2021156787-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2021-08-12 | — | — | WO | disclosed |