Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 4/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23723834 | 1.00 | PARP10 (0.40) | PARP10PARP11PIM1PIM2PARP1 | |
| SCHEMBL23723816 | 0.85 | PARP10 (0.44) | PARP10PARP11PARP1KDR | |
| SCHEMBL24069033 | 0.82 | PARP10 (0.31) | PARP10PARP11PIM1PIM2RORC | |
| SCHEMBL21593327 | 0.78 | PARP10 (0.47) | PARP10PARP11PARP1NCOA1NCOA3 | |
| SCHEMBL28900724 | 0.77 | PARP10 (0.39) | PARP10PARP11PARP1 | |
| SCHEMBL23723787 | 0.75 | KDM4E (0.37) | RORCDHODH | |
| SCHEMBL23723789 | 0.75 | KDM4E (0.37) | RORCDHODH | |
| SCHEMBL15813600 | 0.75 | RORC (0.38) | PARP10PARP11PIM1PIM2PARP1 | |
| SCHEMBL21593493 | 0.75 | PARP10 (0.44) | PARP10PARP11PARP1 | |
| SCHEMBL21593302 | 0.75 | PARP10 (0.44) | PARP10PARP11PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100124-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Janssen Biotech, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021156787-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2021-08-12 | — | — | WO | disclosed |