Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23723789 | 1.00 | KDM4E (0.37) | KDM4EGAASMN1; SMN2LMNACYP3A4 | |
| SCHEMBL31496906 | 0.81 | KDM4E (0.38) | KDM4EGAASMN1; SMN2LMNACYP3A4 | |
| SCHEMBL31496832 | 0.76 | CYP3A4 (0.53) | KDM4EGAASMN1; SMN2LMNACYP3A4 | |
| SCHEMBL23723834 | 0.75 | PARP10 (0.40) | RORCDHODH | |
| SCHEMBL23723784 | 0.75 | PARP10 (0.40) | RORCDHODH | |
| SCHEMBL28900677 | 0.75 | KDM4E (0.33) | KDM4EGAASMN1; SMN2LMNACYP3A4 | |
| SCHEMBL23723783 | 0.74 | RORC (0.31) | RORC | |
| SCHEMBL29914938 | 0.73 | KDM4E (0.41) | KDM4EGAASMN1; SMN2LMNACYP3A4 | |
| SCHEMBL27002518 | 0.73 | KDM4E (0.41) | KDM4EGAASMN1; SMN2LMNACYP3A4 | |
| SCHEMBL30546380 | 0.72 | KDM4E (0.36) | KDM4EGAASMN1; SMN2LMNAPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100124-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | Janssen Biotech, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021156787-A1 | HETEROCYCLIC COMPOUNDS AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | JANSSEN BIOTECH, INC. (US) | 2021-08-12 | — | — | WO | disclosed |