Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 4/20 | 0.40 |
| ▸ | MYC | P01106 | 8/20 | 0.40 |
| ▸ | RBP4 | P02753 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2381481 | 0.95 | CFTR (0.42) | CFTRMYCRBP4HSD17B10KDM4E | |
| SCHEMBL2373031 | 0.94 | MYC (0.44) | CFTRMYCHSD17B10GRIA1GRIA2 | |
| SCHEMBL2371652 | 0.90 | CFTR (0.39) | CFTRMYCRBP4HSD17B10KDM4E | |
| SCHEMBL17103826 | 0.89 | CFTR (0.42) | CFTRMYCRBP4HSD17B10KDM4E | |
| SCHEMBL22775054 | 0.88 | CFTR (0.48) | CFTRMYCRBP4HSD17B10KDM4E | |
| SCHEMBL13518970 | 0.86 | CFTR (0.42) | CFTRMYCRBP4HSD17B10KDM4E | |
| SCHEMBL2372871 | 0.84 | CFTR (0.45) | CFTRMYCRBP4HSD17B10KDM4E | |
| SCHEMBL14786282 | 0.82 | MYC (0.40) | CFTRMYCRBP4HSD17B10KDM4E | |
| SCHEMBL2372372 | 0.82 | MYC (0.43) | CFTRMYCRBP4HSD17B10KDM4E | |
| SCHEMBL2383885 | 0.82 | MYC (0.43) | CFTRMYCRBP4HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020250116-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF, COPD, AND BRONCHIECTASIS | NOVARTIS AG (CH) | 2020-12-17 | — | — | WO | disclosed |
| EP-2547656-B1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF | NOVARTIS AG (CH) | 2015-09-30 | — | — | EP | disclosed |
| WO-2013038378-A1 | Pyridine amide derivatives | NOVARTIS AG (CH) | 2013-03-21 | — | — | WO | disclosed |
| EP-2547656-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF | Novartis AG (CH) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011113894-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF | NOVARTIS AG (CH) | 2011-09-22 | — | — | WO | disclosed |