Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 4/20 | 0.39 |
| ▸ | MYC | P01106 | 4/20 | 0.38 |
| ▸ | RBP4 | P02753 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2381481 | 0.94 | CFTR (0.42) | CFTRMYCRBP4ALDH1A1KDM4E | |
| SCHEMBL2383885 | 0.93 | MYC (0.43) | CFTRMYCRBP4ALDH1A1KDM4E | |
| SCHEMBL2372480 | 0.90 | CFTR (0.40) | CFTRMYCRBP4ALDH1A1KDM4E | |
| SCHEMBL2372346 | 0.89 | CFTR (0.42) | CFTRMYCRBP4ALDH1A1KDM4E | |
| SCHEMBL2373031 | 0.83 | MYC (0.44) | CFTRMYCHSD17B10 | |
| SCHEMBL2372871 | 0.83 | CFTR (0.45) | CFTRMYCRBP4ALDH1A1KDM4E | |
| SCHEMBL14786282 | 0.81 | MYC (0.40) | CFTRMYCRBP4ALDH1A1KDM4E | |
| SCHEMBL2372372 | 0.81 | MYC (0.43) | CFTRMYCRBP4ALDH1A1KDM4E | |
| SCHEMBL29699381 | 0.80 | CFTR (0.45) | CFTRMYCRBP4ALDH1A1KDM4E | |
| SCHEMBL2372633 | 0.80 | CFTR (0.45) | CFTRMYCRBP4ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3980121-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF, COPD, AND BRONCHIECTASIS | Novartis AG (CH) | 2022-04-13 | — | — | EP | disclosed |
| WO-2020250116-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF, COPD, AND BRONCHIECTASIS | NOVARTIS AG (CH) | 2020-12-17 | — | — | WO | disclosed |
| EP-2547656-B1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF | NOVARTIS AG (CH) | 2015-09-30 | — | — | EP | disclosed |
| WO-2013038378-A1 | Pyridine amide derivatives | NOVARTIS AG (CH) | 2013-03-21 | — | — | WO | disclosed |
| EP-2547656-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF | Novartis AG (CH) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011113894-A1 | PYRIDINE AND PYRAZINE DERIVATIVE FOR THE TREATMENT OF CF | NOVARTIS AG (CH) | 2011-09-22 | — | — | WO | disclosed |