Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.51 |
| ▸ | PLG | P00747 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.42 |
| ▸ | PIM1 | P11309 | 5/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5814027 | 0.87 | ALDH1A1 (0.54) | CYP2A6ALDH1A1KDM4EMAPTIMPDH2 | |
| SCHEMBL6819310 | 0.83 | CYP2A6 (0.58) | CYP2A6ALDH1A1KDM4EMAPTIMPDH2 | |
| SCHEMBL29957436 | 0.83 | CYP2A6 (0.58) | CYP2A6ALDH1A1KDM4EMAPTIMPDH2 | |
| SCHEMBL7487153 | 0.81 | CYP2A6 (0.57) | CYP2A6ALDH1A1KDM4EMAPTIMPDH2 | |
| SCHEMBL29152827 | 0.80 | CYP2A6 (0.54) | CYP2A6ALDH1A1KDM4EMAPTIMPDH2 | |
| SCHEMBL1081911 | 0.77 | CYP2A6 (1.00) | CYP2A6ALDH1A1KDM4EMAPTIMPDH2 | |
| SCHEMBL29951219 | 0.77 | CYP2A6 (1.00) | CYP2A6ALDH1A1KDM4EMAPTIMPDH2 | |
| SCHEMBL29955610 | 0.76 | CYP2A6 (0.51) | CYP2A6ALDH1A1KDM4EMAPTIMPDH2 | |
| SCHEMBL9377060 | 0.75 | CYP2A6 (0.66) | CYP2A6ALDH1A1KDM4EMAPTIMPDH2 | |
| SCHEMBL29956305 | 0.75 | CYP2A6 (0.66) | CYP2A6ALDH1A1KDM4EMAPTIMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |