Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 14/20 | 0.47 |
| ▸ | MAOA | P21397 | 13/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14843503 | 0.90 | CA9 (0.57) | MAOBMAOACA9CMA1AHR | |
| SCHEMBL29754233 | 0.90 | CA9 (0.57) | MAOBMAOACA9CMA1AHR | |
| SCHEMBL10264374 | 0.84 | MAPT (0.53) | MAPTMAOBMAOACA9NPC1 | |
| SCHEMBL290258 | 0.81 | AHR (0.61) | MAOBMAOACA9CMA1AHR | |
| SCHEMBL10264476 | 0.81 | MAPT (0.50) | MAPTMAOBMAOACA9NPC1 | |
| SCHEMBL2913394 | 0.81 | CA9 (0.51) | MAPTMAOBMAOACA9NPC1 | |
| SCHEMBL29638042 | 0.78 | CMA1 (0.66) | MAPTMAOBMAOACA9CMA1 | |
| SCHEMBL2429992 | 0.78 | CMA1 (0.66) | MAPTMAOBMAOACA9CMA1 | |
| SCHEMBL14796816 | 0.77 | MAOA (0.51) | MAPTMAOBMAOACA9NPC1 | |
| SCHEMBL7505614 | 0.76 | MAPT (0.59) | MAPTCA9CMA1AHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |