Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 7/20 | 0.42 |
| ▸ | MAOA | P21397 | 6/20 | 0.42 |
| ▸ | HTR1A | P08908 | 6/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10264476 | 0.85 | MAPT (0.50) | CA9MAPTMAOBMAOAHTR1A | |
| SCHEMBL23725485 | 0.81 | MAPT (0.53) | CA9MAPTMAOBMAOAKIF11 | |
| SCHEMBL10264374 | 0.81 | MAPT (0.53) | CA9MAPTMAOBMAOAKIF11 | |
| SCHEMBL995002 | 0.79 | CA9 (0.80) | CA9MAPTMAOBMAOAKIF11 | |
| SCHEMBL8176674 | 0.78 | MAOA (0.50) | CA9MAPTMAOBMAOAHTR1A | |
| SCHEMBL19980196 | 0.78 | MAOA (0.57) | MAOBMAOAHTR1ASLC6A4SLC6A2 | |
| SCHEMBL13156609 | 0.78 | CA9 (0.62) | CA9MAOBMAOAAOC3NPC1 | |
| Methane SCHEMBL28569951 | 0.78 | CA9 (0.77) | CA9MAPTMAOBMAOAKIF11 | |
| SCHEMBL31497412 | 0.76 | PPARG (0.43) | CA9MAPTHTR1ASLC6A2SLC6A3 | |
| SCHEMBL2907966 | 0.75 | MAPT (0.53) | MAPTMAOBMAOAKIF11NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |