Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.57 |
| ▸ | GPR139 | Q6DWJ6 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21733175 | 0.81 | PDE10A (0.53) | PDE10AGPR139HTR1ADRD2HTR2A | |
| SCHEMBL9379524 | 0.74 | HTR1A (0.48) | GPR139HTR1ADRD2HTR2ASLC6A4 | |
| SCHEMBL14969795 | 0.74 | PDE10A (1.00) | PDE10A | |
| SCHEMBL22092133 | 0.74 | GPR139 (0.49) | PDE10AGPR139 | |
| SCHEMBL23725860 | 0.69 | PDE10A (0.56) | PDE10AGPR139 | |
| Trifluoroacetic Acid SCHEMBL22092248 | 0.68 | GPR139 (0.46) | PDE10AGPR139 | |
| SCHEMBL16241259 | 0.66 | PDE10A (0.67) | PDE10AGPR139DRD2 | |
| SCHEMBL23859405 | 0.64 | ADORA2A (0.43) | PDE10A | |
| SCHEMBL21363498 | 0.62 | SLC5A2 (0.42) | PDE10AGPR139 | |
| SCHEMBL13896321 | 0.62 | MEN1 (0.37) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |