Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.54 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.45 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.38 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 8/20 | 0.35 |
| ▸ | DRD2 | P14416 | 8/20 | 0.35 |
| ▸ | HTR2A | P28223 | 8/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 4/20 | 0.33 |
| ▸ | HTR6 | P50406 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23725860 | 0.82 | PDE10A (0.56) | PDE10AGPR139SLC5A1SLC5A2KDM4E | |
| SCHEMBL23725342 | 0.79 | PDE10A (0.54) | PDE10AGPR139KDM4EALDH1A1 | |
| SCHEMBL23725814 | 0.77 | PDE10A (0.49) | PDE10AGPR139SLC5A1SLC5A2HTR1A | |
| SCHEMBL17379486 | 0.75 | PDE10A (0.50) | PDE10AGPR139SLC5A1SLC5A2HTR1A | |
| SCHEMBL22092249 | 0.74 | GPR139 (0.48) | PDE10AGPR139SLC5A1SLC5A2KDM4E | |
| SCHEMBL17141031 | 0.74 | PDE10A (0.47) | PDE10AGPR139SLC5A1SLC5A2HTR6 | |
| SCHEMBL22206303 | 0.73 | GPR139 (0.47) | PDE10AGPR139SLC5A1SLC5A2KDM4E | |
| Hydrochloric Acid SCHEMBL22206372 | 0.72 | GPR139 (0.47) | PDE10AGPR139SLC5A1SLC5A2KDM4E | |
| SCHEMBL17141321 | 0.70 | GPR139 (0.58) | PDE10AGPR139SLC5A1SLC5A2KDM4E | |
| SCHEMBL17141252 | 0.70 | GPR139 (0.56) | PDE10AGPR139SLC5A1SLC5A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230143612-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA CORP (US) | 2023-05-11 | — | — | US | disclosed |
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230143612-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | HAVCR2, HMBS, VHL | PDE10A 4271/4885GPR139 3018/4885SLC5A1 1773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.