Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23726761 | 1.00 | METTL3 (0.36) | METTL3IRAK4KCNA5KDM4ELMNA | |
| SCHEMBL25673165 | 0.87 | IRAK4 (0.36) | METTL3IRAK4KDM4EMAPTPOLB | |
| SCHEMBL23726367 | 0.87 | KDM4E (0.46) | KDM4ELMNAMAPTALDH1A1POLB | |
| SCHEMBL23725743 | 0.83 | IRAK4 (0.36) | IRAK4KCNA5KDM4ELMNAMAPT | |
| SCHEMBL23726596 | 0.83 | MEN1 (0.37) | IRAK4KCNA5LMNAMAPTALDH1A1 | |
| SCHEMBL23725967 | 0.80 | MEN1 (0.34) | IRAK4KCNA5KDM4ELMNAMAPT | |
| SCHEMBL23726763 | 0.76 | KDM4E (0.40) | METTL3KDM4ELMNAALDH1A1POLB | |
| SCHEMBL25664421 | 0.74 | KDM4E (0.47) | KDM4ELMNAMAPTALDH1A1POLB | |
| SCHEMBL25687517 | 0.71 | IRAK4 (0.35) | IRAK4ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL25664201 | 0.71 | IRAK4 (0.35) | IRAK4KDM4EALDH1A1IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230143612-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA CORP (US) | 2023-05-11 | — | — | US | disclosed |
| EP-4100381-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158481-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230143612-A1 | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME | HAVCR2, HMBS, VHL | METTL3 773/4885IRAK4 1378/4885KCNA5 3984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.