Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536287 | 0.87 | ADRB1 (0.36) | DRD2DRD3 | |
| SCHEMBL25340231 | 0.85 | — | — | |
| SCHEMBL27224961 | 0.84 | ENPP1 (0.33) | DDB1CRBNDRD2DRD3 | |
| SCHEMBL25340885 | 0.84 | DDB1 (0.31) | DDB1CRBN | |
| SCHEMBL23536575 | 0.82 | DRD2 (0.42) | DDB1CRBNDRD2 | |
| SCHEMBL23536286 | 0.82 | DRD2 (0.33) | DDB1CRBNDRD2 | |
| SCHEMBL22835213 | 0.79 | DDB1 (0.57) | DDB1CRBN | |
| Hydrochloric Acid SCHEMBL30393221 | 0.78 | DDB1 (0.56) | DDB1CRBN | |
| SCHEMBL22835167 | 0.78 | DDB1 (0.33) | DDB1CRBN | |
| SCHEMBL25931519 | 0.78 | DDB1 (0.45) | DDB1CRBNDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100004-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158634-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |