Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 2/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RPA1 | P27694 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30845885 | 0.85 | ALDH1A1 (0.45) | APOBEC3AAPOBEC3GKDM4EALDH1A1POLB | |
| SCHEMBL23728645 | 0.83 | APOBEC3A (0.49) | APOBEC3AAPOBEC3GKDM4EALDH1A1GAA | |
| SCHEMBL21033151 | 0.83 | KDM4E (0.48) | KDM4EALDH1A1GAAPOLBHSD17B10 | |
| SCHEMBL31035784 | 0.80 | KDM4E (0.49) | KDM4EALDH1A1GAAPOLBHPGD | |
| SCHEMBL15287379 | 0.80 | APOBEC3A (0.53) | APOBEC3AAPOBEC3GKDM4EALDH1A1GAA | |
| SCHEMBL17141136 | 0.80 | KDM4E (0.43) | APOBEC3AAPOBEC3GKDM4EALDH1A1GAA | |
| SCHEMBL22672595 | 0.80 | APOBEC3A (0.49) | APOBEC3AAPOBEC3GKDM4EALDH1A1GAA | |
| SCHEMBL23728605 | 0.79 | APOBEC3A (0.51) | APOBEC3AAPOBEC3GKDM4EALDH1A1GAA | |
| SCHEMBL5133266 | 0.76 | APOBEC3A (0.49) | APOBEC3AAPOBEC3GKDM4EALDH1A1HSD17B10 | |
| SCHEMBL545249 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1GAAPDE10ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100004-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| WO-2021158634-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |