Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | TNF | P01375 | 6/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10273425 | 0.86 | GRM2 (0.43) | HTR2AHTR2CTNFCYP1A2LMNA | |
| SCHEMBL21241821 | 0.82 | TNF (0.43) | HTR2AHTR2CTNFPSMB1PSMB5 | |
| SCHEMBL3517454 | 0.82 | TNF (0.43) | HTR2AHTR2CTNFPSMB1PSMB5 | |
| SCHEMBL31241139 | 0.81 | PSMB1 (0.55) | HTR2AHTR2CTNFDDR1PSMB1 | |
| SCHEMBL21241822 | 0.80 | HTR2C (0.46) | HTR2AHTR2CTNFHDAC3HDAC1 | |
| SCHEMBL13591316 | 0.80 | POLB (0.51) | LMNA | |
| SCHEMBL26700308 | 0.79 | PSMB1 (0.41) | HTR2AHTR2CTNFDDR1PSMB1 | |
| SCHEMBL349421 | 0.77 | CYP2A6 (0.42) | CYP1A2CYP2A6 | |
| SCHEMBL29809320 | 0.77 | TNF (0.55) | TNFPSMB1PSMB5 | |
| SCHEMBL179072 | 0.77 | TNF (0.55) | TNFPSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155321-A2 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |