Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CASP2 | P42575 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GLP1R | P43220 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14561105 | 0.96 | TSHR (0.51) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL25009847 | 0.88 | TSHR (0.49) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL15463112 | 0.87 | TSHR (0.47) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL26700977 | 0.87 | EPHX2 (0.43) | TSHRHPGDLMNAKMT2AALDH1A1 | |
| SCHEMBL22473696 | 0.87 | TSHR (0.42) | TSHRHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL25536719 | 0.86 | TSHR (0.62) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL18306913 | 0.86 | MEN1 (0.45) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL12834880 | 0.85 | TSHR (0.59) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL23319057 | 0.85 | HPGD (0.40) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL29299850 | 0.85 | HPGD (0.40) | TSHRHPGDKDM4ELMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155321-A2 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |