Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CASP2 | P42575 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12384295 | 0.89 | TSHR (0.53) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL21947703 | 0.88 | TSHR (0.73) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL20022933 | 0.86 | TSHR (0.59) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL22858759 | 0.86 | TSHR (0.70) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL23729451 | 0.85 | TSHR (0.51) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL12934640 | 0.85 | TSHR (0.69) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL23729303 | 0.85 | TSHR (0.64) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL10403771 | 0.84 | TSHR (0.58) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL25536719 | 0.83 | TSHR (0.62) | TSHRHPGDKDM4ELMNAMEN1 | |
| SCHEMBL16248615 | 0.83 | ALDH1A1 (0.57) | TSHRHPGDLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298356-A2 | Multivalent VLA-4 antagonists comprising polymer moieties | ELAN PHARMACEUTICALS, INC. (US) | 2011-03-23 | — | — | EP | disclosed |