Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18133484 | 0.85 | PROKR1 (0.41) | GBA1PROKR1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL22306680 | 0.82 | GBA1 (0.53) | GBA1SMN1; SMN2ALDH1A1KDM4EHTT | |
| SCHEMBL22291030 | 0.81 | HRH3 (0.53) | SMN1; SMN2ALDH1A1KDM4EHRH3LMNA | |
| SCHEMBL21845264 | 0.80 | CTSK (0.36) | SMN1; SMN2ALDH1A1KDM4EHRH3 | |
| SCHEMBL21333424 | 0.80 | POLB (0.53) | PROKR1SMN1; SMN2ALDH1A1KDM4EHRH3 | |
| SCHEMBL786015 | 0.79 | ALDH1A1 (0.41) | PROKR1SMN1; SMN2ALDH1A1KDM4EHTT | |
| SCHEMBL30080735 | 0.79 | ALDH1A1 (0.41) | PROKR1SMN1; SMN2ALDH1A1KDM4EHTT | |
| SCHEMBL24605692 | 0.79 | HRH4 (0.35) | SMN1; SMN2ALDH1A1KDM4EHCRTR1HCRTR2 | |
| SCHEMBL13180386 | 0.78 | CCR1 (0.50) | PROKR1SMN1; SMN2ALDH1A1KDM4EHRH3 | |
| SCHEMBL20772844 | 0.78 | BRD4 (0.36) | PROKR1SMN1; SMN2ALDH1A1KDM4EHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021155321-A2 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |