Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | PTGFR | P43088 | 8/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | CTSA | P10619 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2373420 | 0.94 | KDM4E (0.49) | KDM4EGAADHODHPTGFRPDE10A | |
| SCHEMBL2372420 | 0.93 | KDM4E (0.46) | KDM4EGAADHODHPTGFRCTSA | |
| SCHEMBL2373516 | 0.91 | KDM4E (0.46) | KDM4EGAADHODHPTGFRCTSA | |
| SCHEMBL2373164 | 0.91 | DHODH (0.56) | KDM4EGAADHODHPTGFRPDE10A | |
| SCHEMBL2372979 | 0.91 | DHODH (0.49) | KDM4EGAADHODHPTGFRCTSA | |
| SCHEMBL2373266 | 0.90 | DHODH (0.47) | KDM4EGAADHODHPTGFRPDE10A | |
| SCHEMBL2372676 | 0.90 | DHODH (0.49) | KDM4EGAADHODHPTGFRPDE10A | |
| SCHEMBL2372846 | 0.90 | CTSA (0.41) | KDM4EGAAPTGFRCTSAMRGPRX4 | |
| SCHEMBL2373877 | 0.87 | DHODH (0.49) | KDM4EGAADHODHPTGFRCTSA | |
| SCHEMBL2372892 | 0.87 | DHODH (0.44) | KDM4EGAADHODHPTGFRPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |