Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | PTGFR | P43088 | 10/20 | 0.44 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
| ▸ | CTSA | P10619 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2372420 | 0.93 | KDM4E (0.46) | KDM4EGAADHODHPTGFRCTSA | |
| SCHEMBL2373099 | 0.91 | KDM4E (0.47) | KDM4EGAADHODHPTGFRCTSA | |
| SCHEMBL2372473 | 0.90 | MALT1 (0.42) | KDM4EPTGFRMALT1CTSAMRGPRX4 | |
| SCHEMBL2372979 | 0.89 | DHODH (0.49) | KDM4EGAADHODHPTGFRCTSA | |
| SCHEMBL2373877 | 0.86 | DHODH (0.49) | KDM4EGAADHODHPTGFRCTSA | |
| SCHEMBL2373420 | 0.85 | KDM4E (0.49) | KDM4EGAADHODHPTGFRMRGPRX4 | |
| SCHEMBL2373309 | 0.85 | DHODH (0.50) | KDM4EGAADHODHPTGFRHTT | |
| SCHEMBL2372803 | 0.84 | DHODH (0.47) | KDM4EGAADHODHPTGFRCTSA | |
| SCHEMBL2372522 | 0.83 | DHODH (0.53) | KDM4EGAADHODHPTGFRHTT | |
| SCHEMBL2373164 | 0.82 | DHODH (0.56) | KDM4EGAADHODHPTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119693-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |
| WO-2011119704-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |